Some common heterocyclic compound, 90347-66-3, name is Methyl 3-iodo-4-methylbenzoate, molecular formula is C9H9IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Methyl 3-iodo-4-methylbenzoate
A mixture of methyl 3-iodo-4-methylbenzoate (1.0 g, 3.6 mmol) and CuCN (389 mg, 4.3 mmol) in NMP (10 mL) is stirred at 200 oC for 1 hour with microwave irradiation.The mixture is diluted with EtOAc / toluene (10:1, 50 mL) to afford precipitate, which is separated by filtration through a pad of Celite. The filtrate is washed with water (30 mL x 3), brine (20 mL x 1), dried over sodium sulfate.The insoluble materials are separated by filtration and the filtrate is concentrated.The residue is purified by column chromatography on silica-gel eluting with n-hexane / EtOAc (7:1 to 6:1) to give 511 g (81% yield) of the title compound as a white solid. 1H-NMR (400 MHz, CDCl 3) delta8.27 (1H, d, J = 1.8 Hz), 8.13 (1H, dd, J = 8.6, 1.8 Hz), 7.42 (1H, d, J = 8.6 Hz), 3.94 (3H, s), 2.61 (3H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 90347-66-3, its application will become more common.