In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 627-31-6 as follows. Quality Control of 1,3-Diiodopropane(stabilized with Copper chip)
The beta- lactam carbonyl compound shown in the formula CH3CH2-COCH2CONH-C6H4Cl1.0mmol added 50 ml round-bottomed flask, and then sequentially adding K2CO32.4mmol, 0.10 mmol tetrabutylammonium chloride, ammonium acetate 1.1mmol, 1,3Diiodopropane 1.2mmol and 35mL of deionized water and mix well. The reaction was continued stirring at 20 10.0 hours, the reaction was stopped by filtration, dried and purified by recrystallization after give 6- (4-chloro-anilino) -5-propionyl-3,4-dihydropyran, products yield 96%.
According to the analysis of related databases, 627-31-6, the application of this compound in the production field has become more and more popular.