Adding a certain compound to certain chemical reactions, such as: 19821-80-8, name is 1,3-Dibromo-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19821-80-8, Safety of 1,3-Dibromo-2-iodobenzene
Example 2: 2,2′,6,6′-Tetrabromo-l,l’-biphenyI (III); At -75 C butyllithium (14 mmol) in hexanes (5.6 mL) was added to a solution ofl,3-dibromo-2-iodobenzene (4.3 g, 12 mmol) in diethyl ether (0.18 L). After the solutionwas stirred for 2 h at -75 C, copper(II)chloride (9.7 g, 72 mmol) was added, and thereaction mixture was allowed to attain 25 C over a 12 h period. Cold water was added tothe reaction mixture and the organic layer was separated. The aqueous phase was extractedwith ethyl acetate (2×0.10 L). The combined organic layers were dried over sodium sulfatebefore being evaporated. 2,2′,6,6′-tetrabromo-l,l’-biphenyl precipitates upon treatment ofthe residue with hexanes cooled to -20 C. The product (9.0 g, 33%) is pure enough forfurther reaction;m.p. 214-215 C;.H NMR (CDC13, 400 MHz): 8 = 7.67 (d, J- 8.3 Hz, 4 H), 7.17 (t, J- 8.0 Hz, 2 H).
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