In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 452-79-9, name is 2-Fluoro-1-iodo-4-methylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C7H6FI
25mL reaction flask, adding 360mg (5.6mmol) copper powder, vacuuming for three times, then injecting 10mL dimethyl sulfoxide, 472mg (2mmol) 4-methyl-2-fluoroiodobenzene, 609mg (3mmol) ethyl bromodifluoroacetate, reacted at 80C overnight, the next day, the temperature was lowered to room temperature, extracted with 50 mL of ethyl acetate, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, the solvent was distilled off by rotary evaporation to give a mixture of ethyl 2-(4-methyl 2-fluorophenyl)-2,2-difluoroacetate as a yellow liquid of 310 mg. Used directly in the next step of the reaction.
The synthetic route of 452-79-9 has been constantly updated, and we look forward to future research findings.