Adding a certain compound to certain chemical reactions, such as: 7425-53-8, name is Ethyl 4-iodobutanoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7425-53-8, SDS of cas: 7425-53-8
Ethyl ester 4-Et. DIEA (11.8 g, 91.7 rnmol) was added to a mixture of compound 3 (13.9 g, 45.87 mmol) and ethyl 3- iodobutyrate (13.3 g, 55.05 minol) in a screw-cup bottle, and the reaction mixture was stirred with heating (110 C) for 2 days. After cooling, the reaction mixture was diluted with diethyl ether, passed through a plug of silica gel (eluting with ether), and the filtrate evaporated in vacuo. The residue was dissolved in hexane/ether (3/1) mixture, washed with water, brine and dried over MgSO4. The product 4-Et was isolated by a short path column chromatography (hexane-hexane/ether 10/1; Rf = 0.59 in hexane/ether = 10/1); yield 18.75 g (98.5%) of a clear oil. ?H NMR (300 MHz, CDC13): delta = 0.21 (s, 6 H, SiMe2But), 0.98 (5, 9 H, SiMe2But), 1.26 Ct, J = 7.2 Hz, 3 H, CO2CH2CH3), 1.28 Cs, 6 H, 2xMe), 1.90 Cm, 2 H, NCH2CH2CH2CO2Et), 1.93 (d, J = 0.5 Hz, 3 H, Me), 2.38 Cm, 2 H, NCH2CH2CH2CO2Et), 3.20 (m, 2 H, NCF{2CH2CH2CO2Et), 4.16 (q, J = 7.2 Hz, 2 H, CO2CH2CH3), 5.10 (d, J = 0.5 Hz, 1 H, HC=), 6.02 Cm, 1 H), 6.10 Cm, 1 H), 6.90 Cm, 1 H) ppm.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 4-iodobutanoate, and friends who are interested can also refer to it.