Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 825-98-9, name is 3-Fluoro-4-iodobenzoic acid, A new synthetic method of this compound is introduced below., name: 3-Fluoro-4-iodobenzoic acid
To a solution of 3-fluoro-4-iodobenzoic acid (step-iof Intermediate-27, i.0 g, 3.75 mmol) inDMF (iO mL) was added K2C03 (i.07 g, 7.5i mmol), 2-bromo-N,N-diethylacetamide (i.09 g,5.63 mmol).The reaction mass was stirred at 80-90C for i6 h. The reaction mixture wasquenched with water, extracted with DCM. The organic layers were dried over Na2504 and concentrated to afford 0.500 g of title compound. ?H NMR (300 MHz, DMSO-d6): 8.09- 8.04 (t, J = 6.6 Hz, iH), 7.73-7.70 (t, J = 8.i Hz, iH), 7.60-7.57 (t, J = 7.8 Hz, iH), 5.03 (s, 2H), 3.30-3.i9 (q, J= 7.5 Hz, 4H), i.i7-i.i3 (t, J= 7.5 Hz, 3H), i.04-0.99 (t, J= 7.2 Hz, 3H);MS [M+Hf?: 380.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.