Some common heterocyclic compound, 160976-02-3, name is 5-Bromo-1,3-difluoro-2-iodobenzene, molecular formula is C6H2BrF2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H2BrF2I
A 2 M aqueous Na2CO3 solution (1 .51 mL) is added to a mixture of 5-bromo-1 ,3- difluoro-2-iodo-benzene (1 .00 g) and 5-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)- 2-triisopropylsilanyl-oxazole (1 .87 g) in 1 ,4-dioxane (9 mL) and methanol (3 mL). The mixture is sparged with argon and [1 ,1 ‘-bis(diphenylphosphino)-ferrocene]dichloro- palladium dichloromethane complex (380 mg) is added. The resulting mixture is stirred at 80C overnight. Since the conversion is not complete, the same amounts of 5-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-2-triisopropylsilanyl-oxazole, 2 M aqueous Na2CO3 solution, and catalyst are added and the mixture is again stirred overnight at 80C. The triisopropylsilyl protecting group is cleaved under these conditions. After cooling to room temperature, ethyl acetate and water are added. The aqueous phase is extracted with ethyl acetate and the combined organic phases are washed with brine, dried over MgSO4, and concentrated in vacuo. The residue is chromatographed on silica gel (cyclohexane/ethyl acetate 1 :0? 1 :1 ) to afford the title compound. LC (method 4): tR = 1 .18 min; Mass spectrum (ESI+): m/z = 260/262 (Br) [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 160976-02-3, its application will become more common.