Electric Literature of 51839-15-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51839-15-7, name is Dimethyl 5-iodoisophthalate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
4.10 g (12.8 mmol) dimethyl 5-iodo-isophthalate were dissolved in 80 ml DMF. 3.32 g (20.1 mmol) 2-carbamoyl-phenylboric acid, 3.00 ml (21.6 mmol) TEA, 3.00 ml (167 mmol) water, 75 mg (0.33 mmol) palladium(II)-acetate as well as 102 mg (0.34 mmol) tri-ortho-tolylphosphine were added and the solution was heated to 100 C. for 2.5 h. The reaction solution was cooled and the solvent was distilled off i. vac. The residue was chromatographed on silica gel (gradient: DCM auf DCM/MeOH 7:3). 2.53 g (63%) of 11-a were obtained.RT (HPLC-MS)=2.68 min.ES-MS (M+H)+=314
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 5-iodoisophthalate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Fuchs, Klaus; Eickmeier, Christian; Heine, Niklas; Peters, Stefan; Dorner-Ciossek, Cornelia; Handschuh, Sandra; Nar, Herbert; Klinder, Klaus; US2010/144681; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com