Adding a certain compound to certain chemical reactions, such as: 25245-35-6, name is 2-Iodo-1,4-dimethoxybenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25245-35-6, SDS of cas: 25245-35-6
To a stirred solution of 2-iodo-1,4-dimethoxybenzene (4b, 264 mg; 1.0 mmol) and tert-butyl alcohol (0.25 mL) in glacialacetic acid (0.2 mL) at 0 C was added dropwise over 2 min concentrated H2SO4 (0.3mL). The reaction was stirred at 0 C for 2 h and then allowed to warm to roomtemperature and stirred overnight. Work up consisted of partitioning the reaction mixturebetween water and ethyl acetate, followed by washing the organic layer with dil. aqNaHCO3, water and drying (Na2SO4). Preparative TLC (hexane-CH2Cl2, 1:1) producedrecovered starting material (67 mg) and the product (148 mg; 46%; 62% based onrecovered starting material). Mp 79-82 C (Lit: 81-83 C [3]). 1H-NMR (CDCl3, 500MHz): 1.35 (s, 9H, But), 3.79 (s, 3H, OCH3), 3.83 (s, 3H, OCH3), 6.81 (s, 1H), 7.20 (s,1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-1,4-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kempton, Robert J.; Kidd-Kautz, Taylor A.; Laurenceau, Soizic; Paula, Stefan; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 971 – 975;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com