Related Products of 627-31-6,Some common heterocyclic compound, 627-31-6, name is 1,3-Diiodopropane(stabilized with Copper chip), molecular formula is C3H6I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3,5-bis(4-iodobutyl) pyridine was prepared following a modifiedprocedure reported in the literature [24,25]. 3,5-dimethyl pyridine(1.5 g, 16.0 mmol) in dry THF (32 mL) was treated with Lithium diisopropylamide(19.3 mmol) under nitrogen atmosphere at -30 C for1 h. 1,3-diiodopropane (7.8 g, 32.2 mmol) was then added quickly intothe reaction mixture to produce 3,5-bis(4-bromobutyl)pyridine. Theproduct was purified by silica gel column chromatography using amixture of hexane/EA as eluent to get a light brown colour oil compound(2). Here the yield is around 82%. The synthesis of compound(3) 3,5-bis(4-bromobutyl)pyridine has been done by the same procedureas of compound (2). The synthetic route is given in Scheme 2. 2.2.1.1. Compound 2. 1H NMR (400 MHz, DMSO-d6): delta(ppm) 8.11 (s,2H), 7.59 (s, 1H), 3.33 (t, 4H), 2.67 (t, 4H), 1.82 (m, 4H), 1.59 (m, 4H),13C NMR (100 MHz, CDCl3): delta(ppm) 147.3, 139.7, 137.1, 32.6, 30.1,28.6, 27.3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3-Diiodopropane(stabilized with Copper chip), its application will become more common.
Reference:
Retracted Article; Vekariya, Rohit L.; Dhar, Abhishek; Kumar, Nadavala Siva; Pal, Rumpa; Roy, Subhasis; Organic electronics; vol. 51; (2017); p. 477 – 484;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com