Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6940-76-7, name is 1-Chloro-3-iodopropane, A new synthetic method of this compound is introduced below., Product Details of 6940-76-7
A solution of LDA in THF/heptane/ethylbenzene (2.0 M, 137 mL, 274 mmol) was added slowly over 90 min to a stirring solution of N,N’-diisopropyl-2,3-butanediimine (20.0 g, 119 mmol) in distilled THF (180 mL) under N2, maintained at -78 C and stirred for an additional 5 h. A solution of 1-chloro-3-iodopropane (57.4 g, 280 mmol) in distilled THF (20 mL) was added over 15 min and the mixture was stirred at -78 C under N2. After 15 h, aqueous HCl (1M, 600 mL) was added and the mixture was allowed to stir at room temperature (RT) for 5 h. THF was removed under reduced pressure, and CH2Cl2 (160mL x 3) was used to extract the product from the remaining aqueous layer. The organic layers were combined and washed with HCl (1M, 60mL), H2O (120 mL) and sat. NaHCO3 (120mL), and the organic layer was then dried over MgSO4. The mixture was filtered and the filtrate was concentrated under reduced pressure to yield a crude orange oil. The oil was purified by distillation (133-137 C/0.08 mmHg) to give 6 (22.5 g, 94.1 mmol, 79%) as a yellow oil. 1H NMR (500 MHz,CDCl3): 3.55 (t, J = 6.3, 4H), 2.79 (t, J = 7.1, 4H), 1.85-1.70 (m, 8H). 13C NMR (125MHz, CDCl3): 198.9, 44.4, 35.1, 31.7, 20.2. ESI-MS: m/z 241 ([M + H]+, calcd for C10H1735Cl37ClO2 , 241.17554).
The synthetic route of 6940-76-7 has been constantly updated, and we look forward to future research findings.