Sources of common compounds: 1,3-Diiodopropane(stabilized with Copper chip)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Diiodopropane(stabilized with Copper chip), and friends who are interested can also refer to it.

Related Products of 627-31-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-31-6 name is 1,3-Diiodopropane(stabilized with Copper chip), This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: K2CO3 (3.7g, 26.8mmol) was added to a solution of 3-(4-hydroxyphenyl)-thiazolidine-2,4-dione (10, 2.8g, 13.4mmol) in MeCN (20mL) and stirred for 10min. The appropriate diiodoalkane (80.3mmol) was added and the reaction mixture was stirred at 95C for 7h. After cooling, water (10mL) was added followed by extraction with ethyl acetate. The organic layer was dried over anhydrous MgSO4, filtered and evaporated under reduced pressure. The residue was purified by flash column chromatography (SiO2, n-hexane/ethyl acetate= 3/1 v/v) to afford the desired compounds.4.1.5 61 3-(4-(3-Iodopropoxy)phenyl)thiazolidine-2,4-dione (11a) (0021) White solid, yield: 81%, 4.0g, 1H NMR (400MHz, DMSO-d6) delta: 2.19-2.24 (m, 2H), 3.39 (t, J=6.6Hz, 2H), 4.06 (t, J=4.7Hz, 2H), 4.28 (s, 2H), 7.05 (d, J=7.1Hz, 2H), 7.20 (d, J=7.1Hz, 2H). HRMS (ES+): m/z calculated for C12H12INO3S: 399.9481 [M+Na]+. Found 399.9472.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Diiodopropane(stabilized with Copper chip), and friends who are interested can also refer to it.