Electric Literature of 52548-14-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52548-14-8, name is 2-Iodo-5-methylbenzoic acid, This compound has unique chemical properties. The synthetic route is as follows.
Part A. 2-iodo-5-methyl-benzoic acid benzyl ester A solution of 2-iodo-5-methylbenzoic acid (2 g, 7.6 mmol) in 20 ml DMF was treated with KHCO3 (0.92 g, 9.2 mmol) and then benzyl bromide (1.1 mL, 9.2 mmol). The resulting mixture was stirred overnight at rt under N2. Reaction was poured into water and extracted 3* with EtOAc. Combined extracts were washed with sat’d. NaHCO3 and brine, dried over anh.Na2SO4, filtered and evaporated. Flash chromatography gave the pure benzyl ester (2.62 g, 98%) as a colorless liquid.
The chemical industry reduces the impact on the environment during synthesis 2-Iodo-5-methylbenzoic acid. I believe this compound will play a more active role in future production and life.