Adding a certain compound to certain chemical reactions, such as: 167479-01-8, name is tert-Butyl (3-iodopropyl)carbamate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 167479-01-8, COA of Formula: C8H16INO2
Compound 7?. A solution of 3-bromo-N-(tert-butoxycarbonyl)propylamine23 (1.61g; 5.66mmol) and cyclen glyoxal (1g; 5.15mmol) in freshly distilled THF (25mL) was stirred at room temperature for 3 days until completion, as monitored by TLC. The white powdery precipitate was filtered and washed with diethylether to afford compound 7? (2.25g; 91% yield). 1H NMR (D2O, 300MHz) delta: 3.99-3.45 (m, 9H), 3.33-3.21 (m, 6H), 2.98-2.79 (m, 5H), 2.63-2.47 (m, 2H), 2.21-2.02 (m, 2H, CH2CHNHBoc), 1.48 (s, 9H, C(CH3)3). 13C NMR (D2O, 75MHz) delta: 160.9 (CO), 86.7 (CHam), 84.2 (C(CH3)3), 74.6 (CHam), 64.9, 59.9, 58.9, 54.1, 51.3, 51.0, 50.6, 50.5, 46.5, 39.9 (CH2NHCO), 30.7 (CH2NHCO), 30.7 (C(CH3)3), 26.3 (CH2CH2NHCO). HRMS (ESI): calculated for C18H34N5O2+ [M]+: 352.27070; found: 352.27067.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (3-iodopropyl)carbamate, other downstream synthetic routes, hurry up and to see.