Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3718-88-5, name is 3-Iodobenzylamine hydrochloride, A new synthetic method of this compound is introduced below., Computed Properties of C7H9ClIN
take 5.88 g (21.8 mmol) 3-iodobenzylamine hydrochloride (C1) and 2.06 g (47.96 mmol) cyanamide (C2) to form a mixture that is heated and refluxed at 105 degrees Celsius for 4 hours. After cooling down, add water (10 mL) into the mixture to dissolve completely. Then add 10 mL aqueous solution of sodium bicarbonate (C3) (1.83 g, 21.8 mmol) to obtain an insoluble solid (precipitate). After filtering, washing with cold water, acetone and ether and drying, the compound C4 (6.7 g, 91%) is obtained.Analysis of the synthesis product: IR (KBr) nu 3352 (NH), 1697 (CO) cm-1. 1H NMR (CD3OD) delta 7.71 (s, 1 H, C6H4), 7.68 (d, J=7.8 Hz, 1 H, C6H4), 7.33 (d, J=7.8 Hz, 1 H, C6H4), 7.15 (t, J=7.8 Hz, 1 H, C6H4), 4.36 (s, 2 H, CH2). 13C NMR (CD3OD) delta 160.51 (CO), 157.67 (CN), 139.27, 136.92, 136.12, 130.52, 126.41 and 94.0 (C6H4), 43.58 (CH2)
The synthetic route of 3718-88-5 has been constantly updated, and we look forward to future research findings.