Electric Literature of 5876-51-7, These common heterocyclic compound, 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A suspension of aryl halide (1.0 mmol), K2CO3 (2.0 mmol), Fe3O4SiO2-EDTA-Pd (0.008 g, 0.4 mol%) in H2O/DMF [2/1 (v/v)] (3 mL) was mixed in a reaction flask and n-butylacrylate or styrene (1.2 mmol) was added. The reaction mixture was stirred at 100 C for an appropriate time. After completion of the reaction (monitored by TLC), it was cold at room temperature, diluted with ethyl acetate (10 mL) and then the catalyst was separated from the solution by an external magnetic field. The organic phase was separated and dried over MgSO4 and the solvent was then removed under reduced pressure. Pure products were obtained after isolation of the residue by column chromatography on silica (hexane/ethyl acetate).
Statistics shows that 5-Iodobenzo[d][1,3]dioxole is playing an increasingly important role. we look forward to future research findings about 5876-51-7.