Application of 90347-66-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90347-66-3 name is Methyl 3-iodo-4-methylbenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 3-IODO-4-METHYL-BENZOIC acid methyl ester (13.50 g, 48.92 MMOL) in THF (260 mL) was added 2 M solution of ISOPROPYLMAGNESIUM chloride in THF (24.5 mL, 49.00 MMOL) AT-50C. After the reaction mixture was stirred at the same temperature for 30 min, compound 440 (13.39 G, 40.70 MMOL) was added. The solution was warmed up to room temperature and stirred at the same temperature for 2 h. The reaction was then quenched with saturated aqueous solution of NH4CI. The aqueous phase was extracted twice with diethyl ether. The combined organic phases were dried over MGS04 and concentrated in vacuo. The crude material was taken up in ethanol and heated for reflux. The obtained solution was cooled down to room temperature. The crystals were filtered off and dried
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-iodo-4-methylbenzoate, and friends who are interested can also refer to it.