The synthetic route of 58313-23-8 has been constantly updated, and we look forward to future research findings.
Electric Literature of 58313-23-8, A common heterocyclic compound, 58313-23-8, name is Ethyl-3-iodobenzoate, molecular formula is C9H9IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of ethyl 3-iodobenzoate (13.16 g, 47.70 mmol) in THF at -30 to -40 0C isopropylmagnesium chloride (23.8 mL of a 2M solution, 47.70 mmol) was added dropwise. The resulting mixture was stirred for one hour before 5- chloro-2-methylbenzaldehyde (7.0 g, 45.3 mmol) was added. The reaction mixture was stirred at -30 0C for 30 min, then warmed to room temperature and stirred for an additional 10 min. Aqueous NH4Cl and EtOAc were added and the layers separated. The organic layer was then washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The crude material was purified using silica gel chromatography to afford 10.2 g of ethyl 3-[(5-chloro-2- methylphenyl)(hydroxy)methyl]benzoate (70% yield).
The synthetic route of 58313-23-8 has been constantly updated, and we look forward to future research findings.