Adding a certain compound to certain chemical reactions, such as: 289039-83-4, name is Methyl 2-amino-5-bromo-3-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 289039-83-4, COA of Formula: C8H7BrINO2
[0323] Pent-4-yn-l-ol (35.4 mg, 0.42 mmol), methyl 2-amino-5-bromo-3-iodobenzoate (100 mg, 0.28 mmol) ,PdCl2(PPh3)2 (45.9 mg, 0.06 mmol), DIEA (0.098 mL, 0.56 mmol)and copper(I) iodide (10.70 mg, 0.06 mmol) were suspended in THF (2 mL) under nitrogen. The reaction was stirred at rt for 2 hours. The solvent was removed. The crude product was purified by flash silica chromatography, elution gradient 0 to 80% EtOAc in petroleum ether. Pure fractions were evaporated to dryness to afford methyl 2-amino-5-bromo-3-(5-hydroxypent-l-yn-l-yl)benzoate (0954) (80 mg, 91 %) as a brown solid (80 mg, 91%). XH NMR (300 MHz,CDCl3-d6) delta ppm 1.67 – 1.76 (2H,m), 2.50 – 2.57 (2H, m), 3.50 – 3.82 (2H, m), 3.82 (3H, s), 4.58 (1H, tr), 6.76 (2H, brs), 7.52 (1H, d), 7.79(1H, d). LC-MS (Method A): m/z (ES+), [M+H]+ = 312.2; acid, HPLC tR = 1.54 mm.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-5-bromo-3-iodobenzoate, other downstream synthetic routes, hurry up and to see.