These common heterocyclic compound, 1829-28-3, name is Ethyl 2-iodobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C9H9IO2
In a test tube equipped with a stirring bar and a septum rubber,Under argon flow, bis (trifluoromethyl) zinc (DMPU) 2 complex (92 mg, 0.2 mmol),After adding copper (I) chloride (1.9 mg, 0.01 mmol), DMPU (0.2 ml) and ethyl 2-iodobenzoate (0.1 mmol, 16.6 mul)Replace septum rubber with screw cap,The reaction was carried out at 50 ° C. for 24 hours.After completion of the reaction,After cooling,As a result of quantification by 19 F-NMR using benzotrifluoride using the reaction solution as an internal standard substance,The yield of the objective ethyl 2- (trifluoromethyl) benzoate was 82percent.
The synthetic route of Ethyl 2-iodobenzoate has been constantly updated, and we look forward to future research findings.