In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21304-38-1 as follows. Formula: C6H7IN2
A solution of 4-iodo-benzene-l,2-diamJne (0.46g, 1.96mmol), ethanedial [40% in water] (2.25mL), acetic acid (ImL) and ethanol (2OmL) were heated to 1000C for several hours and then cooled to room temperature. Water was added and the crude product was extracted with ethyl acetate. The product was purified via silica gel column chromatography with hexane: ethyl acetate (1:1) to give 0.323g (64%) of 6- iodo-quinoxaline. 1H NMR (400 MHz, CDCl3) S 8.77 (dd, 2H, J=2.0, 8.8Hz), 8.46 (d, IH, 2.0Hz), 7.96 (dd, IH, J=2.0, 8.8Hz), 7.75 (d, IH, J=8.8Hz).
According to the analysis of related databases, 21304-38-1, the application of this compound in the production field has become more and more popular.