In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 629-09-4, name is 1,6-Diiodohexane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1,6-Diiodohexane
A suspension of sodium hydride (60%, 0.48 g, 12 mmol) in 20 ml of DMF was prepared. 1-(2-Chloro-5-thiazolylmethyl)-2-nitroiminoimidazolidine (2.61 g, 10 mmol) was added to this suspension. The resulting mixture was then stirred for 1 hour at room temperature. 1,6-Diiodohexane (1.64 g, 5 mmol) was added dropwise to this reaction mixture over the course of 30 minutes while cooling the reaction mixture with ice. Following completion of dropping, the mixture was stirred for 4 hours at room temperature. The DMF was distilled off from the reaction mixture under reduced pressure. The residue was then shaken with a mixture of water and chloroform. After separating the chloroform layer and drying, the solvent was distilled off under reduced pressure. The semi-solid residue was subjected to silica gel column chromatography with a mixture (15:1 (v/v)) of ethyl acetate and ethanol as the eluate. The crude product was recrystallized from methanol. The yield of crystalline product was 0.22 g (70%), and the melting point was 204 to 206 C. The results of elementary analysis and NMR analysis are shown below. [0117] Elementary Anal., Found (Calc.): C 36.80 (36.67), H 4.51 (4.33), N 23.50 (23.13). [0118] NMR (CDCl3, delta, ppm): 1.34 (4H, m), 1.60 (4H, m), 3.32 (4H, t, J=7.3), 3.66 (4H, m) , 3.77 (4H, m) , 4.57 (4H, s), 7.49 (2H, s). [0119] Based on the results of analysis, the compound of Example 14 was determined to be 1,6-bis[1-(2-chloro-5-thiazolylmethyl)-2-nitroiminoimidazolidin-3-yl]hexane having the structural formula indicated below.
The synthetic route of 629-09-4 has been constantly updated, and we look forward to future research findings.