These common heterocyclic compound, 2468-56-6, name is 6-Iodohex-1-yne, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H9I
General procedure: A mixture of the corresponding precursor (1 eq) and alkylating agent (1.5 eq) and K2CO3 (2.5 eq) in DMF was stirred at rt till completion of the reaction. H2O was added and the mixture was extracted with EtOAc. The organic layer was dried, filtered and evaporated. The crude compound was used in next reaction step without further purification (it can be impure with the corresponding precursor).
The synthetic route of 6-Iodohex-1-yne has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III (F.S.P. CNIO); PASTOR FERNANDEZ, Joaquin Angel; BLASCO MARHUENDA, Maria Antonia; MARTINEZ GONZALEZ, Sonia; BLANCO-APARICIO, Carmen; GARCIA GARCIA, Ana Belen; VARELA BUSTO, Carmen; GOMEZ-CASERO ESTEBAN, Elena; BEJARANO BOSQUE, Leire; MENDEZ PERTUZ, Marinela; MARTINEZ RODRIGUEZ, Paula; GARCIA-BECCARIA, Maria; (71 pag.)EP3623370; (2020); A1;,
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