Related Products of 69113-59-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 69113-59-3 name is 3-Iodobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a stirred solution of the corresponding beta-enaminone 7 (1.8 mmol) in DMF (0.45 mL) at room temperature under argon was added (i-Pr)2NH (3.6 mL), PdCl2(PPh3)2 (0.036 mmol) and CuI (0.036 mmol) in turn and the reaction mixture was stirred for 10 min. The appropriate aryl iodide (2.8 mmol) was then added and the resulting mixture was stirred at room temperature for approximately 3-5 h (Note that stirring was continued until beta-enaminone 7 was completely consumed as monitored by routine TLC). After the reaction was over, ethyl acetate (50 mL) was added, and the resulting solution was washed with 0.1 N HCl (10 mL) and subsequently with a saturated NH4Cl solution (10 mL) in a separatory funnel. After the layers were separated, organic phase was dried over MgSO4 and evaporated on a rotary evaporator to give the crude product, which was purified by flash chromatography on silica gel using hexane/ethyl acetate (9:1 followed by 4:1) as the eluent to afford the corresponding beta-enaminone 4.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Iodobenzonitrile, and friends who are interested can also refer to it.
Reference:
Article; Karabiyikoglu, Sedef; Kelgokmen, Yilmaz; Zora, Metin; Tetrahedron; vol. 71; 25; (2015); p. 4324 – 4333;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com