Reference of 791642-68-7, These common heterocyclic compound, 791642-68-7, name is 4-Bromo-1-iodo-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4-bromo-l-iodo-2-methoxy-benzene (642 mg, 2.05 mmol) in anhydrous tetrahydrofuran (5 mL) was added n-BuLi (2.5 M, 820 uL) at -70C under a nitrogen for 30 min. Then, (¡À)-2-methyl-N-(oxetan-3-ylidene)propane-2-sulfinamide (360 mg, 2.05 mmol) in anhydrous tetrahydrofuran (5 mL) was added at -70C under a nitrogen for 30 min. The reaction mixture was stirred at 25C for 30 min. On completion, the reaction was quenched with saturated ammonium chloride (8 mL) and concentrated in vacuo to remove tetrahydrofuran. The residue was extracted with ethyl acetate (3 X 20 niL), dried over anhydrous sodium sulfate and concentrated in vacuo. The yellow oil was purified by silica gel chromatography (petroleum ether: ethyl acetate = 3 : 1 to 1 : 1) to give the title compound. LCMS: (ES+) m/z (M+l) + = 362.1, tR = 0.777.
The synthetic route of 791642-68-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (358 pag.)WO2017/156165; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com