Some common heterocyclic compound, 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, molecular formula is C6H2F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3,4,5-Trifluoroiodobenzene
Method for preparing ethyl 2,2-difluoro-2- (3,4,5-trifluorophenyl) acetate 3,4,5-trifluoroiodobenzene (10.0 g, 38.0 mmol),Ethyl bromodifluoroacetate (23.1 g, 114 mmol)And a solution of copper (2.90 g, 45.6 mmol) in dimethylsulfoxide (40 ml)Was stirred at 80 C. for 3 hours. Ethyl acetate was added to the reaction mixture, and insoluble matter was filtered off. Pour water into the filtrate,And extracted with ethyl acetate. The extract was washed with saturated brine,After drying with anhydrous sodium sulfate,And concentrated under reduced pressure. The concentrate was purified by silica gel column chromatography (elution solvent: ethyl acetate / n-hexane = 1/10) to give the title compound as a colorless oil (yield 7.20 g, yield 75%). J = 7.3 Hz), 1.31 (3H, t, J = 7.3 Hz), 1 H NMR spectrum (CDCl 3) sigma: 7.26 (2H, t, J = 6.9 Hz), 4.31 ).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 170112-66-0, its application will become more common.
Reference:
Patent; Hokko Chemical Industry Co., Ltd.; Suzuki, Jun; Kobayashi, Yuta; Murakami, Hideyuki; Ono, Ryuta; Onoue, Shinji; Ota, Shinya; Nonaka, Hisato; (29 pag.)JP2016/84347; (2016); A;,
Iodide – Wikipedia,
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