Adding a certain compound to certain chemical reactions, such as: 2265-91-0, name is 1,3-Difluoro-5-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2265-91-0, Recommanded Product: 1,3-Difluoro-5-iodobenzene
To a stirred solution of 1 ,3-difluoro-5-iodobenzene (50.0 g, 208.3 mmol) in DMF (250 ml) was added portionwise MeSNa (14.6 g, 208.3 mmol). The reaction was heated at 150C for 1 h. Further MeSNa (1.5 g, 21 mmol) was added and the reaction was stirred at 150C for a further 30 min. The reaction mixture was allowed to cool to rt before being diluted with distilled water (250 ml) and then extracted five times with MTBE (5 x 150 ml). The combined organic layers were then washed three times with brine (3 x 150 ml). The organic layer was dried (MgS04), filtered and concentrated in vacuo to afford a yellow oil (61 g). This oil was combined with 54 g batch from another synthesis to give a combined total of 115 g (429 mmol). This was purified by silica column chromatography (n- heptane) to afford a colourless oil (84.18 g, 76 %). 1 H NMR (CDCI3; 400 MHz): d: 7.31 (s, 1 H), 7.18 (m, 1 H), 6.88 (m, 1 H), 2.45 (s, 3H).
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Reference:
Patent; BENEVOLENTAI BIO LIMITED; BROWN, Alan; GLEN, Angela; (115 pag.)WO2020/39209; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com