Application of 2401-21-0, A common heterocyclic compound, 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, molecular formula is C6H3Cl2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 97 d-1-(4′-Amino-3′-chloro-5′-fluoro-phenyl)-2-tert.butylamino-ethanol 0.26 gm of d-1-(4′-amino-3′-fluoro-phenyl)-2-tert.butylamino-ethanol hydrochloride and 0.2 ml of pyridine were dissolved in 30 ml of tetrahydrofuran, and the solution was cooled to 0¡ã C. 0.3 gm of iodobenzene dichloride were added, the mixture was held at 0¡ã C. for 2 hours, and then 0.1 gm of iodobenzene dichloride was added again. After standing for 20 hours at about 4¡ã C. the solution was evaporated, and the residue was distributed between ethyl acetate and water. The aqueous phase was made alkaline with 2N ammonia and was then extracted again with ethyl acetate. The organic phase was washed with water, dried and evaporated to dryness in vacuo. The residue was dissolved in absolute ethanol, the solution was neutralized with ethanolic hydrochloric acid, and the hydrochloride of the above-named compound was caused to crystallize by addition of ether. M.p. 210¡ã-211¡ã C. (decomp.). [alpha]36420 = +139.6¡ã (c = 2.0; methanol).
The synthetic route of 2401-21-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Boehringer Ingelheim GmbH; US4119710; (1978); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com