Electric Literature of 19099-54-8, These common heterocyclic compound, 19099-54-8, name is 1-Iodo-2-isopropylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
0.3 mmol of sodium carbonate, 0.1 mmol of 1,2-bis(4-methoxyphenyl)acetylene, 0.005 mmol of palladium acetate, 0.005 mmol of bis(2-diphenylphosphinophenyl)ether, and pinacol borate 0.15mmol, 0.15mmol of 2-isopropyliodobenzene and 1mL of N,N-dimethylformamide were added to a 15mL reaction tube, and the nitrogen was repeatedly filled 10 times, placed in an oil bath at 120 C for 24 hours; cooling The reaction solution was diluted with ethyl acetate to room temperature.Wash three times with water, dry the organic phase with anhydrous Na2SO4, and filter.concentrate,Purification by thin layer chromatography gave 24.7 mg of the desired product.The yield was 51%. The nuclear magnetic and high resolution mass spectra of this compound are characterized as follows:
The synthetic route of 19099-54-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Huaqiao University; Cheng Guolin; Lv Weiwei; (10 pag.)CN109879899; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com