Related Products of 25309-64-2, The chemical industry reduces the impact on the environment during synthesis 25309-64-2, name is 1-Ethyl-4-iodobenzene, I believe this compound will play a more active role in future production and life.
Anhydrous K2CO3 (2.76 g, 20 mmol), L-proline (230 mg, 2 mmol),CuI (95mg, 0.5mmol), added to a 100ml three-necked reaction flask, protected by N2,DMSO (20 ml), 1-cyclopropyl-1,3, -butanedione (0.59 ml, 5 mmol),1-ethyl-4-iodobenzene (0.724 ml, 5 mmol) was magnetically stirred, the reaction temperature was 90 C., and the reaction was performed for 18 h. TLC monitoring (PE: EA = 20: 1).Work-up: After the reaction solution was cooled to room temperature, suction filtration was performed, and the filtrate was extracted with ethyl acetate (EA) (3 ¡Á 10 ml).The organic layers were combined, washed with saturated brine (3 ¡Á 10 ml), and dried over anhydrous Na 2 SO 4.Column chromatography after concentration. The eluent is PE: EA = 70: 1, and dried under vacuum.160 mg of a yellow solid was obtained with a yield of 14%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Ethyl-4-iodobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; China Pharmaceutical University; Li Yuyan; Zeng Fantian; Xu Yungen; Yang Jian; Liu Zhengshi; Li Xiaofang; Ren Longfei; (19 pag.)CN110615808; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com