Synthetic Route of 4387-36-4,Some common heterocyclic compound, 4387-36-4, name is 2-Iodobenzonitrile, molecular formula is C7H4IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
S1: The reaction formula of this step is as follows. The specific reaction operation is: at room temperature,Adding 100 mmol of the compound of the above formula (III) to an appropriate amount of the organic solvent N,N-dimethylacetamide (DMA),200 mmol of the compound of the above formula (IV), 0.4 mmol of palladium acetate,150 mmol of tetra-n-butylammonium bromide and 150 mmol of sodium carbonate,Then, the temperature was stirred to 120 ¡ã C, and the reaction was stirred at this temperature for 15 hours;After the reaction was completed, the reaction mixture was poured into a sufficient amount of ethyl acetate and then washed with saturated brine.The organic layer and the aqueous layer were separated, and the aqueous layer was sufficiently extracted with ethyl acetate.The organic layers are combined (ie, the organic layer washed with saturated brine and the organic layer obtained by ethyl acetate extraction).Dry with anhydrous Na2SO4 and distill under reduced pressure.The residue was eluted by flash column chromatography (a mixture of petroleum ether and ethyl acetate in a volume ratio of 8:1).The eluent was collected and evaporated to remove the eluent.The compound of the above formula (II) was obtained as a white solid in a yield of 87.8percent
The synthetic route of 4387-36-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wenzhou Medical University Affiliated The Second Hospital ? Wenzhou Medical University Affiliated Yuying Child Hospital; Wenzhou Medical University; Wang Zhiyi; Weng Jie; Chen Chan; Wang Zhibin; Zhou Zhiliang; Ma Jianshe; Xu Tong; (18 pag.)CN108250162; (2018); A;,
Iodide – Wikipedia,
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