Related Products of 101335-11-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 101335-11-9, name is 2-Chloro-4-fluoro-1-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows.
To a mixture of (Z)-4-(l-(l-(tetrahydro-2H-pyran-2-yl)-lH-indazol-5-yl)-2-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)but-l-en-l-yl)benzaldehyde IV, 1.2 equivalents of 2- chloro-4-fluoro-l-iodobenzene, 1.0 mol% palladium acetate (CAS Reg. No. 003375-31-3) and 2.7 mol% triphenylphosphine (CAS 000603-35-0) in THF is added 5.0 equivalents of 15 %-w/w aqueous NaOH at 67 C. The reaction mixture stirred at 67 C for 8 – 12 h. Upon desired conversion, the phases were allowed to settle and the aqueous layer was separated. The organic phase was diluted with toluene and washed with 5% aqueous NaOH followed by water. The organic phase so obtained was concentrated at atmospheric pressure to a desired volume, and then cooled to ambient temperature to give toluene solution (E)-4-(2-(2-chloro- 4-fluorophenyl)-l-(l-(tetrahydro-2H-pyran-2-yl)-lH-indazol-5-yl)but-l-en-l- yl)benzaldehyde III. 1H NMR (300 MHz, DMSO-d6): delta 9.82 (s, 1H), 8.15 (s, 1H), 7.78-7.71 (m, 2H), 7.61 (d, 2H), 7.43-7.27 (m, 3H), 7.15 (m, 3H), 5.86 (dd, 1H), 3.93-3.85 (m, 1H), 3.79-3.68 (m, 1H), 2.44-2.36 (m, 3H), 2.10-1.96 (m, 2H), 1.81-1.67 (m, 1H), 1.63-1.53 (m, 2H), 0.92 (t, 3H); LCMS: 405 [(M-THP+H)+H]+.
The chemical industry reduces the impact on the environment during synthesis 2-Chloro-4-fluoro-1-iodobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BACHMANN, Stephan; FANTASIA, Serena Maria; GOSSELIN, Francis; HAN, Chong; HILDBRAND, Stefan; HUMPHRIES, Theresa; JENNY, Christian; LIM, Ngiap-Kie; MCCLORY, Andrew; MOESSNER, Christian; REGE, Pankaj D.; SAVAGE, Scott; ZHANG, Haiming; (66 pag.)WO2017/60326; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com