Sources of common compounds: 1-Iodo-4-methyl-2-nitrobenzene

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Iodo-4-methyl-2-nitrobenzene, its application will become more common.

Application of 5326-39-6,Some common heterocyclic compound, 5326-39-6, name is 1-Iodo-4-methyl-2-nitrobenzene, molecular formula is C7H6INO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis example 1 4,4′-dimethyl-2-nitro-1,1′-biphenyl A flask, covered with aluminium foil, was charged with 5.0 g (19 mmol) 4-iodo-3-nitrotoluene, 4.14 g (19 mmol) 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolyl)toluene, 20 ml toluene and 20 ml 2 M potassium carbonate (aq). The mixture was evacuated and charged with argon for three times, after which 2 mol% Pd(PPh3)4 was added. Evacuation and filling with argon was repeated once and the mixture was stirred for 60 hours at reflux temperature. The mixture was allowed to cool to room temperature, the organic layer was separated, dried (MgSO4), filtered and concentrated. After column chromatography (SiO2, hexane/dichloromethane, 60/40, v/v) 4.3 g of product was obtained. 1H NMR (CDCl3): delta 7.64 (d, J=1.5 Hz, 1H), 7.41 (dd, J=1.5 Hz, J=8 Hz, 1H), 7.32 (d, J=8 Hz, 1H), 7.26-7.19 (m, 4H), 2.47 (s, 3H), 2.40 (s, 3H). 13C NMR (CDCl3): delta 149, 138, 138, 134, 133, 133, 132, 129, 128, 124, 21, 21.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Iodo-4-methyl-2-nitrobenzene, its application will become more common.

Reference:
Patent; Koninklijke Philips Electronics N.V.; EP1838671; (2008); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com