Related Products of 69113-59-3, A common heterocyclic compound, 69113-59-3, name is 3-Iodobenzonitrile, molecular formula is C7H4IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of n-butyllithium inn-hexane (1.6 M, 7.4 mL, 11.9 mmol) was added to a solutionof m-carborane (1.50 g, 10.8 mmol) in l,2-dimethoxyethane(DME) (12 mL) at 0C under Ar atmosphere, and the mixture was stirred at 0 C for 30 min. Copper(I) chloride (10 mg,104 mmol) was added to the reaction mixture at room temperature. After 1 h, pyridine (3.8 mL) and substituted iodobenzene(11.9 mmol) were added, and the mixture was stirred at 80 C for 2.5 h. After cooling, the reaction mixture was diluted withether, and insoluble materials were filtered off through celite.The filtrate was washed successively with 5% sodium thiosulfate, 2 M hydrochloric acid, and brine, dried over sodiumsulfate, and evaporated. The residue was purified by silicagel column chromatography (eluent: n-hexane-ethyl acetate,20 : 1) to give 10-12.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Mori, Shuichi; Takagaki, Ryohei; Fujii, Shinya; Urushibara, Ko; Tanatani, Aya; Kagechika, Hiroyuki; Chemical and Pharmaceutical Bulletin; vol. 65; 11; (2017); p. 1051 – 1057;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com