Adding a certain compound to certain chemical reactions, such as: 127654-70-0, name is 1-Chloro-3-fluoro-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127654-70-0, SDS of cas: 127654-70-0
b) 2-chloro-4-fluoro-3-iodo-1-nitrobenzene To a solution of 1-chloro-3-fluoro-2-iodobenzene (15.0 g) in concentrated sulfuric acid (75 mL) was added concentrated nitric acid (5.1 mL) at 0 C., and the mixture was stirred at room temperature for 2 hr. After confirmation of completion of the reaction by TLC, the reaction mixture was poured into ice-cooled water and extracted 3 times with ethyl acetate. The combined organic layer was washed with saturated brine, dried over sodium sulfate and concentrated to give a crude purified product of the title compound (15.0 g). The product was used without further purification for the next step.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Chloro-3-fluoro-2-iodobenzene, and friends who are interested can also refer to it.
Reference:
Patent; Takeda Pharmaceutical Company Limited; FUJIMOTO, Jun; LIU, Xin; KURASAWA, Osamu; TAKAGI, Terufumi; CARY, Douglas Robert; BANNO, Hiroshi; ASANO, Yasutomi; KOJIMA, Takuto; (159 pag.)US2019/169166; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com