Application of 1878-94-0,Some common heterocyclic compound, 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, molecular formula is C8H7IO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation Example 10 Synthesis of Compound 10 (0209) (0210) A vial was charged with a carboxylic acid (371 mg, 1 equiv.), a solvent (1 mL of a solution of 200 g N-oxybenzotriazole in 1 L of DMF), and an amine (254 mg, 1 equiv.). To the stirred reaction mixture, EDC was added (228 mg, 1.1 equiv.). In case the reaction mixture became highly viscous, some more DMF was added. In case the reaction mixture was a homogeneous solution, it was kept at room temperature for 72 hrs. Otherwise, the reaction mixture was sonicated at room temperature for 5 days. The reaction mixture was diluted with 1% aqueous sodium phosphate solution until the vial was full. Then the vial was sonicated. In case a crystalline precipitate was formed, the vial was subjected to the filtration. In case an oily product was formed, the product was dissolved in methanol and precipitated by an addition of 4% hydrochloric acid. Alternatively 2-propanol (1 mL) was mixed with the crude product and the mixture was sonicated. Then the solution was diluted with 5% aqueous sodium hydrogen carbonate solution (the procedure repeated 2-3 times if necessary). The crude product was purified by chromatography (silica gel, chloroform: 2-propanol=4:1) The yield was 506 mg (84%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-Iodophenoxy)acetic acid, its application will become more common.
Reference:
Patent; THE UNIVERSITY OF TOKYO; RIKEN; KADOWAKI, Takashi; YAMAUCHI, Toshimasa; IWABU, Miki; IWABU, Masato; YOKOYAMA, Shigeyuki; HONMA, Teruki; (158 pag.)US2016/214967; (2016); A1;,
Iodide – Wikipedia,
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