Related Products of 127654-70-0,Some common heterocyclic compound, 127654-70-0, name is 1-Chloro-3-fluoro-2-iodobenzene, molecular formula is C6H3ClFI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 1-chloro-3-fluoro-2-iodobenzene (0.335 g, 1.30 mmol) in tetrahydrofuran (1.5 mL), isopropylmagnesium chloride lithium chloride (0.878 ml, 1.3 M solution) was added at -10 C and the resulting mixture was stirred for 1 hour before a solution of 3 -(8-(bis(4-methoxybenzyl)amino)-2-formyl-5 -(pyrimidin-4-yl)-[1,2,4jtriazolo[1,5-ajpyrazin-6-yl)benzonitrile (0.190 g, 0.326 mmol) (from Example49 step 8) in THF (1.5 mL) was added at -10 C. The reaction mixture was stirred for60 minutes, then quenched with ammonium chloride solution (3 mL), and extractedwith dichloromethane. The combined organic layers were concentrated undervacuum. The cmde material was directly purified by a silica gel column to afford thedesired product (147 mg, 63%) as a racemic mixture. LC-MS calculated forC39H31C1FN803 (M+H): m/z = 713.2; found 713.3.
The synthetic route of 127654-70-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INCYTE CORPORATION; HOANG, Gia; WANG, Xiaozhao; CARLSEN, Peter Niels; GAN, Pei; LI, Yong; QI, Chao; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHU, Wenyu; (333 pag.)WO2020/10197; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com