Continuously updated synthesis method about Methyl 5-iodo-2-methylbenzoate

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 103440-54-6, name is Methyl 5-iodo-2-methylbenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: 103440-54-6

A solution of compound 7 (39.6 g, 0.143 mol) and 1-vinyl-2-pyrrolidinone (18.5 g, 0.143 mol) in anhydrous THF (200 mL) was added slowly to a gently refluxing suspension of sodium hydride (9.2 g, 60% in mineral oil, 0.229 mol) in THF (70 mL). After the addition, the mixture was stirred at reflux for additional 3 hours. TLC (petroleum ether: ethyl acetate = 10:1) showed the reaction was complete. The mixture was cooled and the excess sodium hydride was EPO quenched with saturated aqueous ammonium chloride. The mixture was concentrated in vacuo to remove THF. The residue was extracted with ethyl acetate (400 ml_x2). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo to give crude product 8, which was used in the next step without further purification.

The synthetic route of 103440-54-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; WO2006/117669; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com