Adding a certain compound to certain chemical reactions, such as: 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31827-94-8, Quality Control of 2-Bromo-1-(4-iodophenyl)ethanone
Example 21; Preparation of compound 1024; Step 1:; 4a9 (30.0 g, 132 mmol) and 21a1 (42.9 g, 132 mmol) are added to a 1 L RBF and the mixture is purged with argon. Anhydrous acetonitrile (300 mL) and diisopropylethylamine (57.5 mL, 330 mmol) are added. Stirring is initiated and the mixture is then agitated at RT until complete conversion (>99 A%, 220 nm with respect to 21a1). The mixture is concentrated via reduced pressure. Toluene (150 mL) is added to the mixture. The mixture is reduced to ~100 mL and is filtered through a filter frit into a 1 L RBF containing ammonium acetate (102 g, 1.32 mol). The original 1 L RBF is rinsed with 2×100 mL of toluene and the washes are passed through the solids within the filter frit. Stirring is initiated and the mixture is purged with argon. The mixture is heated to 98-102 C and agitated for 6 h. The mixture is cooled to RT until complete conversion (>99 A%, 220 nm). The mixture is washed with water. The mixture is again concentrated to via reduced pressure. 1 ,4-dioxane (100 mL) is added and the mixture is reduced. 1 ,4-dioxane (150 mL) is added and the mixture is stirred. The mixture is purged with argon, heated to 45-52 C and agitated until a homogeneous solution is obtained. 264 mL (1.06 mol) of a 4 N HCI solution in 1 ,4-dioxane is added drop-wise. The mixture is agitated at 45-52 C until complete conversion (>99 A, 220 nm). The mixture is cooled to 10-12 C and agitated at 10-12C for 30 min; the solids are collected by filtration. The filtrate is charged back to the RBF and cooled to 10-12 C. The filtrate is passed through the filter pad, and the resulting solids are washed with 1 ,4-dioxane (50 ml.) pre-cooled to 1 1-13 C. The solids are suction dried for 1 h and dried in a vacuum oven at 50C under house vacuum with a nitrogen bleed for 15 h. 21a2 (52.4 g) is recovered.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-(4-iodophenyl)ethanone, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; THIBEAULT, Carl; EDWARDS, Paul, J.; KUHN, Cyrille; MOREAU, Benoit; POIRIER, Maude; SURPRENANT, Simon; WO2012/48421; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com