Introduction of a new synthetic route about 3-Iodo-1-propanol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1-propanol, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 627-32-7, name is 3-Iodo-1-propanol, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-32-7, Computed Properties of C3H7IO

To a solution of 12 (221 mg, 0.42 mmol) in MeOH (5 mL) was added KOH (26 mg, 0.46 mmol). The mixture was stirred at room temperature for 30 min, and then concentrated under reduced pressure to give a potassium salt, which was dissolved in DMF (5 mL) and treated with 3-iodo-1-propanol (52 muL, 0.55 mmol). After stirring at room temperature for 5 h, the mixture was evaporated under reduced pressure. The residue was dissolved in CH2Cl2 (20 mL) and extracted with 1 M HCl and brine. The organic phase was dried over MgSO4, concentrated under reduced pressure, and purified by flash chromatography on a silica gel column (EtOAc/hexane = 1:1) to afford ester 13 (137 mg, 55%). C28H48N4O9; colorless solid, mp 95-97 C; TLC (EtOAc/hexane = 3:1) Rf = 0.28; inlMMLBox -68.0 (c 1.4, CHCl3); IR numax (neat) 3278, 2970, 2932, 1724, 1643, 1610, 1252, 1144, 1055 cm-1; 1H NMR (400 MHz, CDCl3) delta 11.33 (1H, s), 8.58 (1H, d, J = 8.4 Hz), 6.75 (1H, s), 6.51 (1H, d, J = 8.8 Hz), 4.34-4.28 (1H, m), 4.26-4.21 (2H, m), 4.07 (1H, m), 3.97 (1H, d, J = 7.6 Hz), 3.64 (2H, t, J = 6.4 Hz), 3.29 (1H, t, J = 5.6 Hz), 2.73-2.68 (1H, m), 2.33 (1H, dd, J = 17.6, 9.2 Hz), 1.88-1.82 (5H, m), 1.50-1.43 (22H, m), 0.86-0.78 (6H, m); 13C NMR (100 MHz, CDCl3) delta 170.0, 166.0, 162.9, 156.7, 152.3, 138.4, 128.2, 83.5, 82.7, 79.5, 76.1, 61.8, 58.9, 54.3, 48.2, 31.8, 30.7, 28.4 (3¡Á), 28.1 (3¡Á), 26.1, 25.8, 23.4, 9.7, 9.4; ESI-HRMS calcd for C28H48N4O9: 585.3496, found: m/z 585.3500 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Liu, Kung-Cheng; Lee, Pei-Shan; Wang, Shi-Yun; Cheng, Yih-Shyun E.; Fang, Jim-Min; Wong, Chi-Huey; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4796 – 4802;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com