Some common heterocyclic compound, 13194-68-8, name is 4-Iodo-2-methylaniline, molecular formula is C7H8IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-Iodo-2-methylaniline
Compound E (e.g., 4.3mmol) was added in ethyl acetate (e.g., 30mL), water (e.g., 30mL) and sodium hydroxide (e.g., 4.8mmol) were added and the resulting product was used for the subsequent reaction. 2, 2, 2-trichloroethyl chloroformate (e.g., 4.7mmol) was added dropwise to the above solution at 0-5C .Aftercompletionofdropping, the reaction was carried out at room temperature for 1 hour. The organic phase was separated, dried and concentrated under reduced pressure to obtain compound F, the yield was >95%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 13194-68-8, its application will become more common.
Reference:
Patent; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; SHI, Ying; MI, Yi; YANG, Hanyu; WANG, Xuliang; GONG, Denghuang; BAI, Min; CHEN, Xiaozhuo; CHEN, Yujie; ZHANG, Xuejiao; MA, Yuxiu; GAO, Qingzhi; (77 pag.)EP3357916; (2018); A1;,
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