Synthetic Route of 791642-68-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 791642-68-7, name is 4-Bromo-1-iodo-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 5-bromo-2-iodoanisole (0.5 g, 1.6 mmol), morpholine (0.14 mL, 1.6 mmol), Pd2(dba)3 (0.04 g, 0.048 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.08 g, 0.144 mmol) and sodium tert-butoxide (0.46 g, 4.79 mmol) in toluene (10 mL) was heated to 70 C for 20 h. The reaction was diluted with water, extracted with EtOAc, dried and evaporated. The crude product was purified by flash silica chromatography eluting with 0-30% EtOAc/cyclohexane. Pure fractions were evaporated to dryness to give 4-(4-bromo-2- methoxy-phenyl)morpholine, (0.24g, 56%). m/z ES+ [M+H]+ 272/274; 1H NMR (400 MHz, DMSO-d6) d 7.10- 7.04 (m, 2H), 6.82 (d, J = 8.4 Hz, 1H), 3.80 (s, 3H), 3.74- 3.66 (m, 4H), 2.96- 2.89 (m, 4H).
The chemical industry reduces the impact on the environment during synthesis 4-Bromo-1-iodo-2-methoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ARTIOS PHARMA LIMITED; BLENCOWE, Peter; CHARLES, Mark; CRIDLAND, Andrew; EKWURU, Tennyson; HEALD, Robert; MACDONALD, Ellen; MCCARRON, Hollie; RIGOREAU, Laurent; (200 pag.)WO2020/30925; (2020); A1;,
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