Related Products of 16355-92-3, These common heterocyclic compound, 16355-92-3, name is 1,10-Diiododecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 1 (300 mg, 0.67 mmol), 1 ,10-diiododecane (600 mg, 1.5 mmol), 1 M aqueous sodium hydroxide (1.5 ml, 1.5 mmol), tetra-n-butylamonium iodide (27 mg, 0.072 mmol) and water (2 ml) were charged into a 5 ml Biotage microwave vial. The mixture was then irradiated at 1400C for 5 min. The resulting orange solution was extracted with EtOAc and the combined EtOAc fractions were reduced to afford an orange gum. Purification was achieved via column chromatography (loaded onto diatomaceous earth) using 0-14% step gradient of EtOAc in cyclohexane (2% steps) as eluent, followed by 100% cyclohexane, followed by 30% EtOAc in cyclohexane to afford the product as a colorless gum.Yield: 272 mg (57%)LC-MS (Method 3): Rt 5.57 min, m/z 711 [MH+]
The synthetic route of 16355-92-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARGENTA DISCOVERY LTD.; WO2007/42815; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com