Adding a certain compound to certain chemical reactions, such as: 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 181765-86-6, Recommanded Product: Methyl 5-bromo-2-iodobenzoate
The intermediate 1 – 2 (4.0 g, 16.8 mmol) and 5 – bromo -2 – iodo benzoic acid methyl ester (6.3 g, 18.5 mmol) dissolved in 50 ml in tetrahydrofuran and then potassium carbonate (4.56 g, 33.6 mmol), 25 ml water mixed together in single-port is added to the flask. Under the protection of argon, and then added to the mixture (triphenylphosphine) palladium four (0.28 g, 0 . 24 mmol), heating reflux for 4 hours. After the reaction, the reaction mixture can be cooled to the room temperature, and steaming and remove the tetrahydrofuran, then washing, dichloromethane extraction three times (each 10 ml). The combined organic phase, anhydrous sodium sulfate drying, the crude product is used good column chromatography purification, get 5.67 g, yield of 82.7%.
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Reference:
Patent; Shanghai Daoyi Chemical Technology Co., Ltd.; Huang Jinhai; Su Jianhua; (27 pag.)CN107163066; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com