Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 199786-58-8, name is (5-Bromo-2-iodophenyl)methanol, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H6BrIO
In a 1 L 3 -necked round-bottom flask (5-bromo-2-iodophenyl)methanol (14.0 g, 44.7 mmol) and IH-imidazole (6.09 g, 89.0 mmol) were combined with dichloromethane (150 mL). Then ieri-butylchlorodimethylsilane (10.1 g, 67.1 mmol) was added dropwise at 0-4C. The resulting mixture was stirred at ambient temperature for 16 hours then water (50 mL) was added. The resulting mixture was extracted with ethyl acetate (3 x 50 mL) and the combined organic layers were washed with brine (50 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo and the residue purified on silica, eluting with 5-10% ethyl acetate in petroleum ether to afford the title compound. 1H NMR (400 MHz, CDC13) 57.67- 7.62 (m, 2H), 7.15-7.12 (m, 1H), 4.61 (s, 2H), 1.01 (s, 9H), 0.20 (s, 6H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 199786-58-8.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CHILDERS, Matthew Lloyd; DINSMORE, Christopher; FULLER, Peter; GUERIN, David; KATZ, Jason David; PU, Qinglin; SCOTT, Mark E.; THOMPSON, Christopher F.; ZHANG, Hongjun; FALCONE, Danielle; TORRES, Luis; BRUBAKER, Jason; ZENG, Hongbo; CAI, Jiaqiang; DU, Xiaoxing; WANG, Chonggang; BAI, Yunfeng; KONG, Norman; LIU, Yumei; ZHENG, Zhixiang; WO2014/146490; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com