Synthetic Route of 4028-63-1, These common heterocyclic compound, 4028-63-1, name is 2,4,6-Trimethyliodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The reaction was generally performed with 2.0 equivalents of TfOH. m-CPBA (65%active oxidant, 2.6 mmol) and aryl iodide (2.3 mmol) were dissolved in DCM (20 mL)in a sealed tube. The arene (2.6 mmol) was added and the solution was cooled to 0 oC,followed by dropwise addition of TfOH (4.6 mmol), and resulted in a colouredsolution. The reaction mixture was stirred for about 2 h, subsequently concentratedunder vacuum. Et2O was added and the mixture was stirred at room temperature for30 mins to precipitate out an off-white solid.
Statistics shows that 2,4,6-Trimethyliodobenzene is playing an increasingly important role. we look forward to future research findings about 4028-63-1.
Reference:
Article; Liu, Qi-Sheng; Wang, De-Yin; Yang, Jin-Fei; Ma, Zhong-Yi; Ye, Mengchun; Tetrahedron; vol. 73; 26; (2017); p. 3591 – 3595;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com