Related Products of 98-61-3, A common heterocyclic compound, 98-61-3, name is 4-Iodobenzenesulfonyl chloride, molecular formula is C6H4ClIO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: C5-Arylated Furans; General Procedure To a 25-mL oven-dried Schlenk tube, arenesulfonyl chloride (1.5-2 mmol), furan derivative (1 mmol), Li2CO3 (0.222 g, 3 mmol), 1,4-dioxane (2 mL) and PdCl2(MeCN)2 (12.9 mg, 0.05 mmol) wereadded successively. The mixture was evacuated by vacuum-argoncycles (5 ) and stirred at 140 C (oil bath temperature) for 20-72 h(see tables and schemes). After cooling the reaction at r.t. and con-centration, the crude mixture was purified by column chromatogra-phy (silica gel) to afford the C5-arylated furans.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Beladhria, Anissa; Yuan, Kedong; Ben Ammar, Hamed; Soule, Jean-Francois; Ben Salem, Ridha; Doucet, Henri; Synthesis; vol. 46; 18; (2014); p. 2515 – 2523;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com