Adding a certain compound to certain chemical reactions, such as: 869500-07-2, name is 1-Bromo-2-iodo-3-methylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 869500-07-2, name: 1-Bromo-2-iodo-3-methylbenzene
A mixture of 1-bromo-2-iodo-3-methylbenzene (0.46g), {3-[(ethyloxy)- carbonyl] phenyl}boronic acid (0.20g), tetrakis(triphenylphosphine)palladium(0) (60mg), potassium carbonate (0.71g), toluene (6ml) and ethanol (6ml) was stirred under reflux under nitrogen for 3h. The mixture was partitioned between water (40ml) and ether (40ml) and the aqueous layer extracted with ether (15ml). The combined ether extracts were dried (MgS04), evaporated and the residue purified by flash chromatography eluting with 2% ethyl acetate in isohexane to afford the title compound (0.22g). LC/MS Rt = 4.1 min, [MH+] 319/321.
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Reference:
Patent; GLAXO GROUP LIMITED; WO2005/108369; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com