Related Products of 610-97-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 610-97-9, Name is Methyl 2-iodobenzoate, SMILES is O=C(OC)C1=CC=CC=C1I, belongs to iodides-buliding-blocks compound. In a article, author is Liang, JA, introduce new discover of the category.
A novel loss-of-function deletion in sodium/iodide symporter gene in follicular thyroid adenoma
The sodium/iodide symporter (NIS) actively transports iodide into thyrocytes. However, in thyroid carcinoma, down-regulated or mis-targeted NIS expression is commonly found and usually correlates with tumor dedifferentiation and loss of radioiodine uptake capacity. In this study, we screened NIS genes of thyroid tumor tissues from three patients with thyroid carcinoma by using reverse transcription-polymerase chain reaction and nucleotide sequencing. We found a novel exon 6 deletion in NIS gene. We then examined the NIS gene from the blood of this patient. The nucleotide sequences of the flanking region of exon 6 were normal. By transient transfection and I-125 uptake assay, we found that the wild type NIS-expressing HepG2 cells accumulated six times more iodide than mutant and mock HepG2 cells. Our data demonstrated that the exon 6 deletion causes an iodide-trapping defect. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Related Products of 610-97-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 610-97-9 is helpful to your research.