Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 88-67-5, Name is 2-Iodobenzoic acid. In a document, author is Lisa, Thomasz, introducing its new discovery. HPLC of Formula: C7H5IO2.
6 Iodo-delta-lactone reproduces many but not all the effects of iodide
Background: Iodide has direct effects on thyroid function. Several iodinated lipids are biosynthesized by the thyroid and they were postulated as intermediaries in the action of iodide. Among them 6 iodo-delta-lactone (IL-delta) has been identified and proposed to play a role in thyroid autoregulation. The aim of this study was to compare the effect of iodide and IL-delta on several thyroid parameters. Methods: Thyroid bovine follicles were incubated with the different compounds during three days. Results: KI and IL-delta inhibited iodide uptake, total protein and Tg synthesis but only Kt had an effect on NIS and Tg mRNAs levels. Both compounds inhibited Na+/K+ ATPase and deoxy-glucose uptake. As PAX 8, FOXE 1 and TITF1 are involved in the regulation of thyroid specific genes their mRNA levels were measured. While iodide inhibited the expression of the first two, the expression of TITF1 was stimulated by iodide and IL-delta had no effect on these parameters. Conclusion: These findings indicate that IL-delta reproduces some but not all the effects of excess iodide. These observations apply for higher micromolar concentrations of iodide while no such effects could be demonstrated at nanomolar iodide concentrations. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 88-67-5 help many people in the next few years. HPLC of Formula: C7H5IO2.